Faculty – Cellular and Molecular

Klaus W. Beyenbach, Ph.D., Washington State University.  Membrane transport of xenobiotics; organic cation and anion transport in the kidney; epitheliac transport mechanism.  Beyenbach, K.W., and H. Wieczorek.  The V-type H+ Atpase:  Molecular Structure and Function, Physiological Roles and Regulation.  J. Exp. Biol. 209: 577-589, 2006.

Stephen E. Bloom, Ph.D., Pennsylvania State, 1968. Mechanisms of lymphoid-cell sensitivity to drugs and environmental toxicants; in vitro model systems; apoptosis and cell cycle regulatory mechanisms. Muscarella, D.E., K.A. O’ Brien, A.T. Lemley, and S.E. Bloom. “Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the m-benzodiazepine receptor” Toxicological Sciences 74:66-73, (2003).

Kathryn J. Boor, Ph.D., California, Davis, 1994. Bacterial responses to environmental challenges; food microbiology; food safety. Kim, H., H. Marquis, and K. J. Boor. “Sigma B contributes to Listeria monocytogenes invasion by controlling expression of inlA and inlB”. Microbiol. (in press 2005).

Paul R. Bowser, Ph.D. (Fish Pathology), Auburn University, 1978. Evaluation of therapeutic Compounds for treatment of diseases of fish; pathogenesis of tumors in fish caused by retroviruses. Tort, M.J., C. Jennings-Bayshore, D. Wilson, G.A. Wooster and P.R. Bowser. “Assessing the effects of increasing hydrogen peroxide dosage on rainbow trout(Onchorhynchus mykiss) gills utilizing a digitized scoring methodology”. Journal of Aquatic Animal Health. 14:95-103, ( 2002).

James W. Casey, Ph.D., Chicago, 1973. Viral oncogenesis, retroviral and herpesviral host interactions that induce tumors in natural populations of aquatic animals. J. Virol. 8765-71, 1998, Virology 246-99, 1998.

Rodney R. Dietert, Ph.D.,Texas/Austin, 1977. Immunotoxicology; effects of nutrients and environmental chemicals on immune function and ontogeny of the immune system. Dietert, R.R., J-E. Lee, J. Olsen, K. Fitch and J.A., Marsh. “Developmental immunotoxicity of dexamethasone: comparison of fetal vs. adult exposures”. Toxicology, (2003).

Leon Kochian, Ph.D.,University of California, Davis, 1983. Metal ion transport processes in plants, with a particular interest in the roles of ion transport processes in plant responses to environmental stresses, and mechanisms of heavy metal transport, resistance and hyperaccumulation. Papoyan A, and Kochian LV. “Identification of Thlaspi caerulescens genes that may be involved in heavy metal hyperaccumulation and tolerance: Characterization of a novel heavy metal transporting ATPase”. Plant Physiol 136: 3814-3823, (2004).

Motoko Mukai, D.V.M, Ph.D. (Toxicology), University of Illinois at Urbana-Champaign, 2006.  My research group studies toxicological effects of chemical compounds found in food and water, especially in regards to endocrine disrupting compounds that are found in low concentrations but bioaccumulate/biomagnify in the environment.  For current opportunities in the Mukai lab, visit http://foodscience.cals.cornell.edu/graduate/applying/current-opportunities.

Alexander Nikitin, M.D., Ph.D., Pathology, St. Petersburg, Russia, 1988. Mouse models of human cancer, advanced cancer traits in early neoplasia, stem cells and cancer, pathobiology of neoplasias of reproductive and endocrine systems, live imaging and rational targeting of cancer. Cancer Res., 63: 3459-3463, (2003) Cancer Res. 65: 787-796, (2005).

Bendicht U. Pauli, D.V.M., Bern, Switzerland, 1967. Cancer cell biology, cancer invasion, metastasis. Beckley, J.R., B.U. Pauli, and R.C. Elble. “Re-expression of detachment-inducible chloride channel mCLCA5 suppresses growth of metastatic breast cancer cells.” J. Biol. Chem. 279:41634-41641 (2004).

Mark Roberson, Ph.D.,Nebraska-Lincoln, 1990. Molecular mechanisms of hormone action; cell-specific gene regulation and intracellular signal transduction cascades induced by heterotrimeric G-protein-coupled receptors; endocrine disruptors and mammalian reproductive system. Roberson, MS, S Meermann, MI Morasso, JM Mulvaney-Musa and T. Zhang. . “A role for homeobox protein Distal-less 3 in the transcriptional activation of the glycoprotein hormone a subunit gene in choriocarcinoma cells”. Journal of Biological Chemistry, 276: 10016-10024, (2001).

Jeffrey G. Scott, Ph.D.,California/Riverside, 1985. Molecular biology, genetics and evolution of insecticide resistance; pesticide metabolism; gene regulation; insecticide neurotoxicology. Gao, J. and Scott, J. G. “Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the house fly, Musca domestica”. Insect Biochem. Molec. Biol. 36: 387-395 (2006).

Michael L. Shuler, Ph.D. (Chemical Engineering), Minnesota, 1973. Viravaidya, K. and M.L. Shuler. “Incorporation of 3T3-L1 Cells to Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies”. Biotechnol. Prog. 20:590-597,( 2004).

David M. Soderlund, Ph.D.,California/Berkeley, 1976. Biochemical toxicology of insecticides; insecticide neurotoxicology. Soderlund, D. M., J. M. Clark, L. P. Sheets, L. S. Mullin, V. J. Piccirillo, D. Sargent, J. T. Stevens, and M. L. Weiner. “Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment”. Toxicology 171: 3-59, (2002).

Olena K. Vatamaniuk, PhD. Kyiv State University, Ukraine.  Analysis of molecular mechanisms of heavy metal detoxification, with emphasis on transport processes across vacuolaer/lysosomal compartment of plants/animals, required for maintenance of heavy metal tolerance.  Vatamaniuk, O.K., Bucher, E.A., Sundaram, M.V. and Rea, P.A., CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.  J. Biol Chem, 280, 23684-23690, 2005.

Robert Weiss, Ph.D. (Molecular Virology), Baylor College of Medicine, 1997. Molecular mechanisms for the maintenance of genomic stability; cellular responses to genotoxic stress; mouse models for human cancer. Weiss, R. S., P. Leder, and C. Vaziri. “Critical role for mouse Hus1 in a S-phase DNA damage cell cycle checkpoint”. Mol. Cell. Biol. 23:791-803 (2003).

Andrew Yen, Ph.D. (Biophysics), Cornell, 1976. Cancer cell and molecular biology; regulation of the cell cycle and differentiation by retinoids, carcinogens, oncogenes, and tumor suppressor genes.
Yen, A., Varvayanis, S., Smith. J.L., and Lamkin, T.J.: Retinoic Acid Induces Expression of SLP-76: Expression with c-FMS Enhances ERK Activation and Retinoic-Induced Differentiation/G0 Arrest of HL-60 Cells. Eur. J. Cell Biol. 85:117-132, 2006.
Lamkin, T.J., Chin, V., Varvayanis, S., Smith, J.L., Sramkoski, R.M., Jacobberger, J.W., and Yen, A.: Retinoic Acid-induced CD38 Expression in HL-60 Myeloblastic Leukemia Cells Regulates Cell Differentiation or Viability Depending on Expression Levels. J. Cell. Biochem. 97:1328-1338, 2006.
Lamkin, T.J., Chin, V., and Yen, A.: Atra Induces p62DOK1 And P56DOK2 Expression Which Enhances Induced Differentiation and G0 Arrest of HL-60 Leukemia Cells. Amer. J. Hematol. 81:603-615, 2006.
Reiterer, G. and Yen, A.: Inhibition of the Janus Kinase Family Increases ERK1/2 Phosphorylation and Cuases Endoreduplication. Cancer Res. 66:9083-9087, 2006.